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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight-loss in addition to a reduced-calorie diet and exercising.

Using two separate drugs to lose weight naturally can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err on the side of caution and let the FDA do its job and demand some research be done in order that the public recognizes the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to earn money and that they would say anything to keep people on his or her medications.

Researchers found that participants investing in this drug to get a year, dropped excess weight within four weeks and have kept the weight off through the entire 56 weeks with the study. Contrave is often a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs that are made up of several active ingredient, which may make them more effective and safer.

Combo-pilling may be the newest fad or even better the newest to come under scrutiny and so it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular could be the fact that since right now there aren't long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug also can raise blood pressure and heartbeat, and really should not be used in those with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients on the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.


The most common negative effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

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